鼠抗人IL-6抗体

货号：grIL6-04

简介：
Mouse anti-human IL-6 antibody
Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans. IL-6 signaling is mediated by building a complex of IL-6, the transmembrane IL-6 receptor (mIL-6R) or with soluble forms of IL-6R (sIL-6R), and the signal-transducing subunit molecule gp130. Therefore, three modes for IL-6 signaling may occur in which IL-6 is binding to mIL-6R (classic), to sIL-6R (trans-signaling), or is joined through IL-6R to gp130 on nearby located cells (trans-presentation). These pathways, and the fact that gp130 is ubiquitously expressed, lead to the pleiotropic functions of IL-6. The control of IL-6 signaling is regulated through the induction of suppressor molecules after activation of the IL-6 pathways as well as through the presence of sIL-6R and gp130 forms in the blood

其它名称：IL-6单抗，IL-6 antibody

应用：CLIA，POCT

特异性：Human interleukin 6

来源：Mouse

存贮：-20℃

产品说明

白细胞介素-6 (Interleukin-6, IL-6)是促炎细胞因子家族的一员，可诱导多种急性炎症相关蛋白的表达，在人体细胞的增殖和分化过程中发挥重要作用。IL-6信号通过构建IL-6、跨膜IL-6受体(mIL-6R)或与可溶性IL-6R (sIL-6R)和信号转导亚基分子gp130的复合物介导。因此，IL-6的信号转导可能有三种模式:IL-6与mIL-6R结合(经典模式)，与sIL-6R结合(反式信号转导)，或通过IL-6R与附近细胞上的gp130结合(反式呈递)。这些途径以及gp130的普遍表达导致了IL-6的多效性。IL-6信号的控制是通过IL-6通路激活后抑制分子的诱导以及血液中sIL-6R和gp130形式的存在来调节的

This product is for research use only. It is not intended for diagnostic or therapeutic use.

注意事项：

1.本品为蛋白质制剂，未添加任何防腐剂和保护剂，在2-8℃可短期保存

2.本品作为诊断试剂原辅材料，不得直接用于诊断或治疗。