BRL 49653；5-[[4- [2-（甲基-2-吡啶基氨基）乙氧基]苯基]甲基] -2,4-噻唑烷二酮

中文名称

BRL 49653；5-[[4- [2-（甲基-2-吡啶基氨基）乙氧基]苯基]甲基] -2,4-噻唑烷二酮

英文名字

BRL 49653; 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

供应商

开曼生物

产品货号

71740-25

产品新闻

背景资料

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.{7575,8930} Rosiglitazone (BRL 49653) is a prototypical TZD and has served as a reference compound for this class.{8461} Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM.{8461} It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively.{8461} Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years.

产品描述

A potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM

保存建议

建议您在收到开曼生物品牌的Rosiglitazone (25 mg)产品后置于-20度保存，产品有效期为730天.

其他

开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理，艾美捷科技有限公司将为中国客户提供*的开曼生物产品以及客户订制化服务.