68Ga-DOTA-PEG4-LLP2A;Cu-CB-TE1A1P-PEG4-LLP2A

68Ga-DOTA-PEG4-LLP2A;Cu-CB-TE1A1P-PEG4-LLP2A

 单分散PEG，西安齐岳生物自营产品。由于格式和条数，产品不能列明，详细产品价格信息请咨询西安齐岳生物科技有限公司。

描述：

 Malignant melanoma is a highly aggressive cancer, and the incidence of this disease is increasing worldwide at an alarming rate. Despite advances in the treatment of melanoma, patients with metastatic disease still have a poor prognosis and low survival rate. New strategies, including targeted radiotherapy, would provide options for patients who become resistant to therapies such as BRAF inhibitors. Very late antigen-4 (VLA-4) is expressed on melanoma tumor cells in higher levels in more aggressive and metastatic disease and may provide an ideal target for drug delivery and targeted radiotherapy. In this study, we evaluated 177Lu- and 68Ga-labeled DOTA-PEG4-LLP2A as a VLA-4-targeted radiotherapeutic with a companion PET agent for diagnosis and monitoring metastatic melanoma treatment. DOTA-PEG4-LLP2A was synthesized by solid-phase synthesis. The affinity of 177Lu- and 68Ga-labeled DOTA-PEG4-LLP2A to VLA-4 was determined in B16F10 melanoma cells by saturation binding and competitive binding assays,

齐岳生物提供小分子PEG的定制，PEG个数可选(1,2,3,4,5,6,7,8,9,10)

1.PEG接头包含甲氧基和另一个官能团。聚乙二醇化连接子

2.同源双功能PEG接头可交联两个相同的分子。X-PEG-X接头

3.杂芳基PEG接头可交联两个不同的分子。X-PEG-Y接头

4.异双功能PEG接头的每个末端均含有一个氨基和一个羧酸基团。氨基PEG酸

5.DBCO，四嗪，TCO，PTAD和环戊烯等，化试剂，荧光染料，聚乙二醇化糖苷以及PEG交联剂

6.受体靶向试剂，带有叠氮化物部分，用于点击化学

7.含少一个叠氮部分的杂化双功能连接物，用于通过点击反应与炔烃或环炔对映体共轭。我们在另一端有各样的功能组来满足您的需要。

8.DBCO-PEG4-DBCO是一种同双功能叠氮-叠氮交联剂

相关定制产品：

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