锌指蛋白798抗体-智慧城市网

产品详情

产品货号 : mlR13174

英文名称 : FIZ1

中文名称 : 锌指蛋白798抗体

别名 : FLJ00416; FLJ14768; FLT3 interacting zinc finger 1; Flt3 interacting zinc finger protein 1; Zinc finger protein 798; ZNF798; FIZ1_HUMAN.

研究领域 : 细胞生物神经生物学转录调节因子表观遗传学

抗体来源 : Rabbit

克隆类型 : Polyclonal

交叉反应 : Human, Mouse, Rat, Pig, Cow, Sheep,

产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 : 52kDa

细胞定位 : 细胞核细胞浆

性状 : Lyophilized or Liquid

浓度 : 1mg/ml

免疫原 : KLH conjugated synthetic peptide derived from human FIZ1/ZNF798:21-120/496

亚型 : IgG

纯化方法 : affinity purified by Protein A

储存液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed : PubMed

产品图片:

产品介绍 : Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. FIZ1 (FLT3-interacting zinc finger 1), also known as ZNF798 (zinc finger protein 798), is a 496 amino acid zinc-finger protein that contains eleven C2H2-type zinc fingers. Localized to both the cytoplasm and the nucleus and expressed in a wide variety of tissues, FIZ1 is thought to repress the function of Nrl (neural retina leucine zipper) in photoreceptors, possibly regulating the expression of rod-specific genes. Additionally, FIZ1 interacts with the receptor-related tyrosine kinase Flt-3/Flk-2 and, via this interaction, may be involved in the regulation of lymphoid and hematopoietc cells.

Function:

FIZ1 is a zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. It also interacts with a transcription factor that regulates the expression of rod-specific genes in retina.

Subunit:

Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).

Subcellular Location:

Cytoplasm. Nucleus.

Tissue Specificity:

Widely expressed.

Similarity:

Contains 11 C2H2-type zinc fingers.

SWISS:

Q96SL8

Gene ID:

84922

Important Note:

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.