04-0006-Stemolecule™ PD0325901（MEK抑制剂）

Stemolecule™ PD0325901（MEK抑制剂）

产品关键词：

MEK；naïve stem cells 初始干细胞；neural progenitor cells 神经祖细胞；WH-4-023；CHIR99021；CAS：391210-10-9；

产品描述：

PD0325901是一种靶向MAPK（MAPK/ERK kinase 或MEK）的小分子，具潜在的抗肿瘤活性。PD0325901是MEK抑制剂CI-1040的衍生物，选择性结合和抑制MEK，可能引起MAPK/ERK的磷酸化和活化，抑制肿瘤细胞增殖。与ALK5抑制剂SB431542一起，PD0325901能够提高人原代成纤维细胞重编程为诱导多潜能干细胞（iPS）的能力。

Stemgent公司提供支持初始潜能干细胞应用需要的5i/L/A培养基添加剂（5i/L/A media supplment）所有成分，如下：

产品特性

1. 同义名：N-​[(2R)-​2,​3-​dihydroxypropoxy]-​3,​4-​difluoro-​2-​[(2-​fluoro-​4-​iodophenyl)amino]-​benzamide
2. 分子式：C₁₆H₁₄F₃IN₂O₄
3. 分子量：482.19 g/mol
4. CAS NO: 391210-10-9
5. 纯度：＞97%（HPLC）
6. 外观：Pale purple solid
7. 溶解性：DMSO
8. 保存和稳定性：粉末4 °C避光保存，重溶后的储存液分装后-20 °C保存，6个月稳定。
9. 质量控制：HPLC测定纯度，MS测定准确分子量，PD0325901对小鼠胚胎干细胞的细胞毒性测试。
10. 结构图：

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引用文献：

• Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)
• Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)
• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)
• DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)
• Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)
• Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)
• Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)
• Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).
• Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .
• Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)
• Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Schöler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.
• Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self renewal. Nature 453: 519-523.

 — —Written/Edited by V. Shallan【版权归MKBio懋康所有】

上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信”的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。

Stemolecule™ PD0325901（MEK抑制剂）

Stemolecule™ PD0325901（MEK抑制剂）

Stemolecule™ PD0325901（MEK抑制剂）