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β淀粉样蛋白胞内结构域相关蛋白1抗体

  • 产地
  • 所在地
  • 美、英
  • 上海上海市

更新时间:2024-06-05

有效日期:还剩356

产品详情

更多抗体
我们提供的抗体用于实验研究,而不用于诊临床断或治疗程序。
β淀粉样蛋白胞内结构域相关蛋白1抗体Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名称 Anti-ANKS1B/AIDA1
中文名称 β淀粉样蛋白胞内结构域相关蛋白1抗体
别 名 AIDA 1; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; E2A-PBX1-associated protein; EB-1.
浓 度 1mg/1ml
规 格 0.2ml/200μg
β淀粉样蛋白胞内结构域相关蛋白1抗体抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep
产品类型 一抗
研究领域 细胞生物 免疫学 神经生物学 Alzheimer's
蛋白分子量 predicted molecular weight: 138kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ANKS1B/AIDA1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The β-Amyloid protein precursor (AbPP) is a widely expressed transmembrane protein that is processed into the b-Amyloid (Ab) peptide, which accumulates in insoluble plaques in the brain of Alzheimer’s disease patients and AbPP intracellular domain (AID). AID may function as a pro-apoptotic peptide, a regulator of calcium homeostasis and a molecule involved in transcriptional regulation. The AID associated protein 1 (AIDA-1) is highly expressed in the brain and is regulated by AbPP. It interacts with AbPP to play a role in brain development. AIDA-1 also interacts with coilin in Cajal bodies to regulate pre-mRNA splicing.
Function : Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
Isoform 3 can regulate global protein synthesis by altering nucleolar numbers (By similarity).
Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Subunit : Isoform 3 interacts with DLG4 (By similarity). Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
Subcellular Location : Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
Tissue Specificity : Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
Post-translational modifications : Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage (By similarity).
Similarity : Contains 7 ANK repeats.
Contains 1 PID domain.
Contains 2 SAM (sterile alpha motif) domains.
Database links : UniProtKB/Swiss-Prot: Q7Z6G8.2
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