β淀粉样蛋白胞内结构域相关蛋白1抗体

更多抗体
我们提供的抗体用于实验研究，而不用于诊临床断或治疗程序。
β淀粉样蛋白胞内结构域相关蛋白1抗体Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名称 Anti-ANKS1B/AIDA1
中文名称 β淀粉样蛋白胞内结构域相关蛋白1抗体
别 名 AIDA 1; AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN; E2A-PBX1-associated protein; EB-1.
浓 度 1mg/1ml
规 格 0.2ml/200μg
β淀粉样蛋白胞内结构域相关蛋白1抗体抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep
产品类型 一抗
研究领域 细胞生物 免疫学 神经生物学 Alzheimer's
蛋白分子量 predicted molecular weight: 138kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ANKS1B/AIDA1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The β-Amyloid protein precursor （AbPP） is a widely expressed transmembrane protein that is processed into the b-Amyloid （Ab） peptide, which accumulates in insoluble plaques in the brain of Alzheimer’s disease patients and AbPP intracellular domain （AID）. AID may function as a pro-apoptotic peptide, a regulator of calcium homeostasis and a molecule involved in transcriptional regulation. The AID associated protein 1 （AIDA-1） is highly expressed in the brain and is regulated by AbPP. It interacts with AbPP to play a role in brain development. AIDA-1 also interacts with coilin in Cajal bodies to regulate pre-mRNA splicing.
Function : Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
Isoform 3 can regulate global protein synthesis by altering nucleolar numbers （By similarity）.
Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Subunit : Isoform 3 interacts with DLG4 （By similarity）. Interacts with EPHA8. Isoform 2 interacts with COIL. Isoform 4 interacts with APP and EPHA8. Isoform 6 interacts with EPHA8.
Subcellular Location : Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors （NMDARs） in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
Tissue Specificity : Highly expressed in marrow from patients with pre-B ALL associated with the t（1;19） translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain （at protein level）. Isoform 6 is expressed in brain and several cancer cell lines.
Post-translational modifications : Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage （By similarity）.
Similarity : Contains 7 ANK repeats.
Contains 1 PID domain.
Contains 2 SAM （sterile alpha motif） domains.
Database links : UniProtKB/Swiss-Prot: Q7Z6G8.2
A21138 雷公藤乙素 Tripdiolide HPLC≥98% 20mg/支
A21139 雷公藤红素 Celastrol HPLC≥98% 20mg/支
A21140 雷公藤内酯甲  wilforlide A HPLC≥98% 20mg/支
A21141 木犀草素 Luteolin HPLC≥98% 20mg/支
A21142 木犀草苷 Cynaroside HPLC≥98% 20mg/支
A21143 没食子酸 Gallic acid HPLC≥98% 20mg/支
A21144 蒙花苷 Buddleoside HPLC≥97% 20mg/支
A21145 莽草酸 Shikimic acid HPLC≥98% 20mg/支
A21146 芹菜素 Apigenin HPLC≥98% 20mg/支
A21147 青藤碱 Sinomenine HPLC≥98% 20mg/支
A21148 齐墩果酸 Oleanolic acid 滴定法≥98% 20mg/支
A21149 七叶皂苷钠 Sodium Aescinate HPLC≥98% 20mg/支
A21150 木糖醇 Xylitol HPLC≥98% 20mg/支
A21151 盐酸育亨宾 Yohimbine Hydrochloride HPLC≥98% 20mg/支
A21152 烟碱 Nicotine HPLC≥98% 20mg/支
A21153 金雀花碱（野靛碱） Cytisine HPLC≥98% 20mg/支
A21154 秋水仙碱 Colchicine HPLC≥98% 20mg/支
A21155 薯蓣皂苷元 Diosgenin HPLC≥98% 20mg/支
A21156 薯蓣皂苷 Dioscin HPLC≥98% 20mg/支
A21157 原薯蓣皂甙 Protodioscin HPLC≥98% 20mg/支
A21158 蛇床子素 Osthole HPLC≥98% 20mg/支
A21159 麝香酮 Muscone GC≥98% 0.15ml
A21160 酚 Kaempferol HPLC≥98% 20mg/支
A21161 水杨苷 Salicin HPLC≥98% 20mg/支
A21162 水飞蓟宾 Silymarin HPLC≥98% 20mg/支
A21163 芸香柚皮苷 Narirutin HPLC≥98% 10mg/支
A21164 芍药苷 Paeoniflorin HPLC≥98% 20mg/支
A21165 鼠李糖 Rhamnose HPLC≥98% 20mg/支
A21166 甜菜碱 Betaine HPLC≥98% 20mg/支
A21167 盐酸甜菜碱 Betaine hydrochloride HPLC≥98% 20mg/支
A21168 甜菊苷 Stevioside HPLC≥95% 20mg/支
A21169 天麻素 Gastrodin HPLC≥98% 20mg/支
A21170 熊果酸 Ursolic acid HPLC≥98% 20mg/支
A21171 熊果苷 Arbutin HPLC≥98% 20mg/支
A21172 辛弗林 Synephrine HPLC≥98% 20mg/支
A21173 香豆素 Coumarin HPLC≥98% 20mg/支
A21174 对香豆酸 p-Coumaric acid HPLC≥98% 20mg/支
A21175 延胡索乙素 Tetrahydropalmatine 滴定法≥98% 20mg/支
A21176 淫羊藿苷 Icariin HPLC≥98% 20mg/支
A21177 柚皮苷 Naringin HPLC≥98% 20mg/支
A21178 柚皮素 Naringenin HPLC≥98% 20mg/支
A21179 原花青素 Proanthocyanidins UV≥95% 20mg/支
A21180 岩白菜素 Bergenin HPLC≥98% 20mg/支
A21181 盐酸青藤碱 Sinomenine HPLC≥98% 20mg/支
A21182 盐酸小檗碱（黄连素） Berberine hydrochloride HPLC≥98% 20mg/支
β淀粉样蛋白胞内结构域相关蛋白1抗体A21183 黄连碱 Coptisine HPLC≥98% 20mg/支
A21184 盐酸黄连碱 coptisine chloride HPLC≥98% 20mg/支
A21185 胡黄连苷-Ⅰ Picroside-Ⅰ HPLC≥98% 20mg/支
A21186 胡黄连苷-Ⅱ Picroside-Ⅱ HPLC≥98% 20mg/支
A21187 胡黄连苷-Ⅲ Picroside-Ⅲ HPLC≥98% 20mg/支
数据奖励办法：如果您使用我公司β淀粉样蛋白胞内结构域相关蛋白1抗体发表了文献，并提交您发表文献的杂志信息，以及发表文献的有效网络链接与产品货号，您也将获得我公司以AM/AP开头的任意抗体小包装一支。
如果在您的实验中使用任何一款我公司一抗产品，并提交您的有效实验数据，您将获得我公司以AM/AP开头的任意抗体小包装一支。