磷酸化相关死亡促进因子抗体

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我们提供的抗体用于实验研究，而不用于诊临床断或治疗程序。
磷酸化相关死亡促进因子抗体Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
英文名称 Anti-Phospho-Bad （Ser136）
中文名称 磷酸化相关死亡促进因子抗体
别 名 Bad （phospho S136）; BAD （Phospho-Ser136）; p-Bad （S136）; p-BAD （Ser136）; p-Bad （phospho S136）; BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡
蛋白分子量 predicted molecular weight: 18kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from mouse BAD around the phosphorylation site of Ser136
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
Function : Promotes cell death. Successfully competes for the binding to Bcl-X（L）, Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X（L）, but not that of Bcl-2 （By similarity）. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Subunit : Forms heterodimers with the anti-apoptotic proteins, Bcl-X（L）, Bcl-2 and Bcl-W. Also binds protein S100A10 （By similarity）. The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins （By similarity）. Interacts with AKT1 and PIM3.
Subcellular Location : Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm.
Tissue Specificity : Expressed in a wide variety of tissues.
Post-translational modifications : Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity.
Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X（L） and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A （CAPK） phosphorylation. Ser-75 is phosphorylated by AKT/PKB, protein kinase A and PIM2.
Similarity : Belongs to the Bcl-2 family.
Database links : UniProtKB/Swiss-Prot: Q92934
BAD是BCL2/BAX、BCL-XL/BAX异二聚体的负调节基因。BAD是BCL2/BCL-XL相关死亡促进因子，作为BCL2、 bCL-XL异二聚体伴分子而促进细胞凋亡。
有学者认为：BAD缺乏典型的羧基端跨膜结构，提示其并非一完整膜蛋白。与同BCL2作用相比，BAD与BCL-XL的结合更强，BAD以浓度依赖性方式替换BCL-XL/BAX、BCL2/BAX异二聚体中的BAX，使BAX游离而促进细胞凋亡。当一细胞系的所有细胞内异二聚体（BCL-XL/BAX和BCL2/BAX）的含量≥50%时，则细胞耐受凋亡；而当细胞内BAX同二聚体＞80%时且在适当信号诱导下则细胞出现凋亡。这表明BAD通过调节BAX同二聚体与异二聚体量的比值而介导凋亡。
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